Formenti, S. C. et al. A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer. Huang, B. et al. This makes him realize for the first time how independent his duplicates actually are.Jamie's health continues to deteriorate due to the Legacy Virus.

Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma. Jamie realizes that if the child of a dupe is merely an "infant dupe", then John's son should have been absorbed either by John himself, or when Jamie ruffled the boys hair; therefore John's son must not be his. However, efforts to develop new immunotherapy agents or combination treatments to increase the proportion of patients who benefit have met with challenges of limited efficacy and/or significant toxicity. Antitumor immunity induction by intracellular hyperthermia using magnetite cationic liposomes. June, C. H. & Sadelain, M. Chimeric antigen receptor therapy. A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma. Charych, D. et al.

Kranz, L. M. et al. Smith, J. D., Morton, L. D. & Ulery, B. D. Nanoparticles as synthetic vaccines.

This work was supported in part by the US National Institutes of Health (awards CA235375, EB022433 and CA206218), the Mayo Clinic–Koch Institute Cancer Solutions Team Grant funding, the Marble Center for Nanomedicine and the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University.

Her best friend Candy, another former mutant, was found dead of a gunshot wound which the police ruled a suicide. In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer. Having his identity uncovered Cortex reveals himself as the second duplicate sent to one of the two "remaining" futures for mutantkind during the "Messiah Complex", to search for a cure for the depowering of 98% of the world's mutants following M-Day, then die in some fashion so that his memories would be transferred back to Madrox.How this duplicate travelled from the alternative future he was sent to Earth-1191 remains a mystery. Molecular-targeted immunotherapeutic strategy for melanoma via dual-targeting nanoparticles delivering small interfering RNA to tumor-associated macrophages. Luo, M. et al. and E.L.D. Pastor, F. et al. Marabelle, A. et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.

When Cortex tried to bring Longshot under his mental and physical control, he noted that Longshot and Shatterstar were in many ways identical.Once she calmed down, Monet told the group that her violent outburst was because of psychic feedback that occurred after she had broken through a psychic barrier in Lenore's mother's mind, but that whatever was controlling her had fled.
An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Ledo, A. M. et al.

Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes. Bachmann, M. F. & Jennings, G. T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Siryn, filled with rage toward Jamie, breaks his finger and tells him to leave.Jamie goes to see his preacher dupe John Maddox.
Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C. & Chan, W. C. Mediating tumor targeting efficiency of nanoparticles through design. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Chen, Q. et al. When she woke up, she grabbed Longshot's throat and said "Cortex".While Strong Guy and Rictor were visiting John Maddox in Vermont, Shatterstar busted through the window and tried to stab Rictor, saying only "Cortex". Photodynamic therapy mediated by nontoxic core–shell nanoparticles synergizes with immune checkpoint blockade to elicit antitumor immunity and antimetastatic effect on breast cancer. Structure-based programming of lymph-node targeting in molecular vaccines.